Dados do Trabalho

Título

Creation and expansion of the Brazilian Von Hippel Lindau disease database

Introdução

Von Hippel-Lindau (VHL) disease is a rare autosomal dominant disorder caused by pathogenic variants in VHL gene. The most common manifestations include hemangioblastomas (HB) of the central nervous system (CNS) and retina (RH); pheochromocytoma (PHEO); clear cell renal cell carcinoma (ccRCC); pancreatic and renal cysts (PRC) and pancreatic neuroendocrine neoplasm (PNEN).

Objetivo

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Métodos

The first characterization of VHL in Brazil was published in 2003 and included 20 families with a history of VHL. In 2023, this database was expanded to include more families, as well as to collect prospectively both clinical and molecular characteristics of patients with VHL to build the VHL Brazilian Registry (VHLBR). Patients with VHL were selected through review of data from medical records of experts and from social networks of support for families with VHL in Brazil. In this report we will present the inclusion of more patients from different cancer centers in Brazil.

Resultados

A total of 142 subjects representing 62 unrelated Brazilian families with VHL were registered. The mean age of VHL onset was 28.78 years old and 128 individuals (90.1%) had at least one VHL-related lesion. CNS HB was the most common manifestation occurring in 91 (71%) patients, followed by multiple PRC (48.4%), RH (39.8%), ccRCC (28.9%), PHEO (12.5%) and PNEN (7.8%). Of the 97 subjects whose presence of VHL variants was confirmed, 51 (52.6%) had missense variants, 22 (22.7%) large deletions, 10 (10.3%) frameshift, 7 (7.2%) splice site, 4 (4.1%) nonsense and 3 (3.1%) in-frame deletions. Regarding surveillance, 115 (81%) participants had at least one physician responsible for their outpatient follow-up; however, 69 (60%) of them did not report a regular frequency of tests.

Conclusões

We built the largest prospective VHL database with organized collections of clinical and genetic data from families with VHL, which will be helpful to guide policies for VHL care and oncogenetics in Brazil.

Palavras-chave

VHL; clinical database; follow-up; genotype-phenotype correlation; von Hippel-Lindau disease.